Sildenafil Citrate generally tolerates very well on all men. A very few cases have been observed where the person experiences reactions and side-effects.

1. The ED drug should not be taken in combination to recreational drugs like poppers.
    
2. The drug interacts with anti-biotic and other heavy doses recommended for curing any other sensual issues.
    
3. Sildenafil Citrate should not be taken if you are involved any heavy medications meant for relieving high blood pressure.
    
4. The drug interacts with drugs prescribed for overcoming prostate hyperplasia
    
5. The medication should be cautiously consumed if you are regularly consuming any anti-depressant.